research

2024

1. Appl. Netw. Sci.

   

   Network analysis of U.S. non-fatal opioid-involved overdose journeys, 2018–2023

   L. H. McCabe, N. Masuda, S. Casillas, N. Danneman, A. Alic, and R. Law

   Applied Network Science, Nov 2024

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   We present a nation-wide network analysis of non-fatal opioid-involved overdose journeys in the United States. Leveraging a unique proprietary dataset of Emergency Medical Services incidents, we construct a journey-to-overdose geospatial network capturing nearly half a million opioid-involved overdose events spanning 2018-2023. We analyze the structure and sociological profile of the nodes, which are counties or their equivalents, characterize the distribution of overdose journey lengths, and investigate changes in the journey network between 2018 and 2023. Our findings include that authority and hub nodes identified by the HITS algorithm tend to be located in urban areas and involved in overdose journeys with particularly long geographical distances.

   @article{mccabe2024overdosenetworks,
     title = {Network analysis of U.S. non-fatal opioid-involved overdose journeys, 2018–2023},
     author = {McCabe, L. H. and Masuda, N. and Casillas, S. and Danneman, N. and Alic, A. and Law, R.},
     journal = {Applied Network Science},
     month = nov,
     year = {2024},
     doi = {https://doi.org/10.1007/s41109-024-00661-z},
   }

2. EMNLP

   

   Prompts have evil twins

   R. Melamed, L. H. McCabe, T. Wakhare, Y. Kim, H. H. Huang, and E. Boix-Adsera

   In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing , Nov 2024

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   We discover that many natural-language prompts can be replaced by corresponding prompts that are unintelligible to humans but that provably elicit similar behavior in language models. We call these prompts “evil twins” because they are obfuscated and uninterpretable (evil), but at the same time mimic the functionality of the original natural-language prompts (twins). Remarkably, evil twins transfer between models. We find these prompts by solving a maximum-likelihood problem which has applications of independent interest.

   @inproceedings{melamed2023propane,
     title = {Prompts have evil twins},
     author = {Melamed, R. and McCabe, L. H. and Wakhare, T. and Kim, Y. and Huang, H. H. and Boix-Adsera, E.},
     editor = {Al-Onaizan, Yaser and Bansal, Mohit and Chen, Yun-Nung},
     booktitle = {Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing},
     month = nov,
     year = {2024},
     address = {Miami, Florida, USA},
     publisher = {Association for Computational Linguistics},
     pages = {46--74},
   }

3. PHM

   

   Large Language Model Agents as Prognostics and Health Management Copilots

   S. Lukens, L. H. McCabe, J. Gen, and A. Ali

   In Annual Conference of the PHM Society , Nov 2024

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   Amid concerns of an aging or diminishing industrial workforce, the recent advancement of large language models (LLMs) presents an opportunity to alleviate potential experience gaps. In this context, we present a practical Prognostics and Health Management (PHM) workflow and selfevaluation framework that leverages LLMs as specialized in-the-loop agents to enhance operational efficiency without subverting human subject matter expertise. Specifically, we automate maintenance recommendations triggered by PHM alerts for monitoring the health of physical assets, using LLM agents to execute structured components of the standard maintenance recommendation protocol, including data processing, failure mode discovery, and evaluation. To illustrate this framework, we provide a case study based on historical data derived from PHM model alerts. We discuss requirements for the design and evaluation of such “PHM Copilots” and formalize key considerations for integrating LLMs into industrial domain applications. Refined deployment of our proposed end-to-end integrated system may enable less experienced and professionals to back-fill existing personnel atreduced costs.

   @inproceedings{lukens2024large,
     title = {Large Language Model Agents as Prognostics and Health Management Copilots},
     author = {Lukens, S. and McCabe, L. H. and Gen, J. and Ali, A.},
     booktitle = {Annual Conference of the PHM Society},
     volume = {16},
     number = {1},
     year = {2024},
   }

4. CISS

   

   Nonparametric Estimation and Comparison of Distance Distributions from Censored Data

   L. H. McCabe

   In 2024 58th Annual Conference on Information Sciences and Systems (CISS) , Mar 2024

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   Transportation distance information is a powerful resource, but location records are often censored due to privacy concerns or regulatory mandates. We outline methods to approximate, sample from, and compare distributions of distances between censored location pairs, a task with applications to public health informatics, logistics, and more. We validate empirically via simulation and demonstrate applicability to practical geospatial data analysis tasks.

   @inproceedings{mccabe2024nonparametric,
     title = {Nonparametric Estimation and Comparison of Distance Distributions from Censored Data},
     author = {McCabe, L. H.},
     booktitle = {2024 58th Annual Conference on Information Sciences and Systems (CISS)},
     pages = {1--6},
     month = mar,
     year = {2024},
     organization = {IEEE},
   }

2023

1. Preprint

   

   Modeling the Operational Feasibility of Synfuel from Seawater

   S. D. Brown, S. M Whittle, L. H. McCabe, B. M. Horio, C. D. Johnson, and M. L. Anderson

   OSF Preprints, Mar 2023

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   Effective deterrence requires confidence in robust naval replenishment capabilities, in order to maintain extended physical presence and support sustained military operations. While many authors have focused on vulcanizing penetration, projection, and defensive capacity, a compelling synergy arises from synthetic fuel generation, which may be conducted near point-of-need. In this work, we consider a modeling and simulation-driven approach to estimating the logistical and operational impacts of marine and aviation fuel from alternative sources. Toward this end, we present the Fuel Replenishment and Logistics Simulation (FuelSim), a novel agent-based fuel paradigm assessment application designed to be lightweight, flexible, and integrable with large-scale systems analyses.

   @article{Brown2023morspreprint,
     title = {Modeling the Operational Feasibility of Synfuel from Seawater},
     url = {osf.io/3auyv},
     doi = {10.31219/osf.io/3auyv},
     journal = {OSF Preprints},
     author = {Brown, S. D. and Whittle, S. M and McCabe, L. H. and Horio, B. M. and Johnson, C. D. and Anderson, M. L.},
     year = {2023},
   }

2022

1. JOSS

   

   cosasi: Graph Diffusion Source Inference in Python

   L. H. McCabe

   Journal of Open Source Software, Dec 2022

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   cosasi (COntagion Simulation And Source Inference) is, to the author’s knowledge, the first extensible open-source framework for graph diffusion source inference that allows users to: perform and evaluate source localization using standard techniques from literature, contribute innovative algorithms to a growing core library, and benchmark new techniques against a battery of comparable schemes. The software is currently used within the Logistics Management Institute. Additional development continues, and we welcome contribution from the broader academic and industrial communities.

   @article{McCabe2022joss,
     doi = {10.21105/joss.04894},
     url = {https://doi.org/10.21105/joss.04894},
     month = dec,
     year = {2022},
     publisher = {The Open Journal},
     volume = {7},
     number = {80},
     pages = {4894},
     author = {McCabe, L. H.},
     title = {cosasi: Graph Diffusion Source Inference in Python},
     journal = {Journal of Open Source Software},
   }

2. I/ITSEC

   

   Modeling Fuel Replenishment Logistics and Impacts of Alternative Synthetic Fuels

   B. Horio, S. Brown, C. Johnson, S. Whittle, M. Anderson, and L. H. McCabe

   In Interservice/Industry Training, Simulation and Education Conference (I/ITSEC) , Dec 2022

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   A critical factor for deterrence and any protracted conflict, is the ability to resupply our forces to maintain extended physical presence, which includes an ability to sustain naval air operations in remote areas. Successfully doing so must also minimize dependency on long-distance transport of fuel across oceans and be resilient to disruption of our fuel supply chain and operation of our fuel distribution facilities. This is a nontrivial logistics challenge as fuel replenishment logistics operate within a highly dynamic and interconnected system of combatants, auxiliaries, and fuel supply points, each with specific processes and behaviors that define how they interact with each other. Current logistics for replenishment of conventional aviation fuel have hard constraints that limit scale (e.g., limited fuel tanker resources) and subject to risk of potential cascading impacts due to disruption at strategic fuel supply points (e.g., calls for the Red Hill facility to halt operations due to groundwater contamination concerns). Toward these risks, ongoing research into alternative fuel sources for sustainable aviation fuel—following the motto, produce it when and where you need it—have increasing importance to national security. Advancing technology for scalable and mobile production of synthetic aviation fuel from alternative sources, such as seawater, promises to redefine naval replenishment logistics. While engineering challenges to make these technologies fully scalable are making progress, the operational feasibility of the adapted logistics must be fully understood. In this paper, we examine the system through a complexity lens and use agent-based simulation to develop an experiment platform to evaluate operational and environmental impacts over a range of scenarios. We propose this approach as useful for establishing relevant baselines, quantifying operational feasibility, providing guidance for the engineering teams, and ultimately characterizing the value proposition of synthetic aviation fuel for naval logistics. Finally, we discuss possible applications (e.g., wargaming).

   @inproceedings{horio2022iitsec,
     title = {Modeling Fuel Replenishment Logistics and Impacts of Alternative Synthetic Fuels},
     author = {Horio, B. and Brown, S. and Johnson, C. and Whittle, S. and Anderson, M. and McCabe, L. H.},
     booktitle = {Interservice/Industry Training, Simulation and Education Conference (I/ITSEC)},
     year = {2022},
     organization = {NTSA},
   }

3. PMLR

   

   The Second NeurIPS Tournament of Reconnaissance Blind Chess

   G. Perrotta, R. W. Gardner, C. Lowman, M. Taufeeque, N. Tongia, S. Kalyanakrishnan, and 7 more authors

   In Proceedings of Machine Learning Research , Dec 2022

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   Reconnaissance Blind Chess is an imperfect-information variant of chess with significant private information that challenges state-of-the-art algorithms. The Johns Hopkins University Applied Physics Laboratory and several organizing partners held the second NeurIPS machine Reconnaissance Blind Chess competition in 2021. 18 bots competed in 9,180 games, revealing a dominant champion with 91% wins. The top four bots in the tournament matched or exceeded the performance of the inaugural tournament’s winner. However, none of the algorithms converge to an optimal, unexploitable strategy or appear to have addressed the core research challenges associated with Reconnaissance Blind Chess.

   @inproceedings{perrotta2022second,
     title = {The Second NeurIPS Tournament of Reconnaissance Blind Chess},
     author = {Perrotta, G. and Gardner, R. W. and Lowman, C. and Taufeeque, M. and Tongia, N. and Kalyanakrishnan, S. and Clark, G. and Wang, K. and Rothberg, E. and Garrison, B. P. and Prithviraj, D. and Canavan, C. and McCabe, L. H.},
     booktitle = {Proceedings of Machine Learning Research},
     pages = {53--65},
     month = dec,
     year = {2022},
     organization = {PMLR},
   }

2017

1. Nature BME

   

   Surveillance nanotechnology for multi-organ cancer metastases

   H. Kantamneni, M. Zevon, M. J. Donzanti, X. Zhao, Y. Sheng, S. R. Barkund, and 5 more authors

   Nature Biomedical Engineering, Dec 2017

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   The identification and molecular profiling of early metastases remains a major challenge in cancer diagnostics and therapy. Most in vivo imaging methods fail to detect small cancerous lesions, a problem that is compounded by the distinct physical and biological barriers associated with different metastatic niches. Here, we show that intravenously injected rare-earth-doped albumin-encapsulated nanoparticles emitting short-wave infrared light (SWIR) can detect targeted metastatic lesions in vivo, allowing for the longitudinal tracking of multi-organ metastases. In a murine model of human breast cancer, the nanoprobes enabled whole-body SWIR detection of adrenal-gland microlesions and bone lesions that were undetectable via contrast-enhanced magnetic resonance imaging as early as three and five weeks post-inoculation, respectively. Whole-body SWIR imaging of nanoprobes functionalized to differentially target distinct metastatic sites and administered to a biomimetic murine model of human breast cancer resolved multi-organ metastases that showed varied molecular profiles in the lungs, adrenal glands and bones. Real-time surveillance of lesions in multiple organs should facilitate pre- and post-therapy monitoring in preclinical settings.

   @article{kantamneni2017surveillance,
     title = {Surveillance nanotechnology for multi-organ cancer metastases},
     author = {Kantamneni, H. and Zevon, M. and Donzanti, M. J. and Zhao, X. and Sheng, Y. and Barkund, S. R. and McCabe, L. H. and Banach-Petrosky, W. and Higgins, L. M. and Ganesan, S. and others},
     journal = {Nature Biomedical Engineering},
     volume = {1},
     number = {12},
     pages = {993--1003},
     month = dec,
     year = {2017},
     publisher = {Nature Publishing Group},
   }

2016

1. WBC

   

   Modulating stem cell-substrate interactions and differentiation by controlling substrate topography via microphase separation

   V. Arvind, S. Vega, L. H. McCabe, P. V. Moghe, S. N. Murthy, and J. Kohn

   Frontiers in Bioengineering and Biotechnology, Mar 2016

   Bib HTML

   @article{varun_sebastian_lucas_prabhas_sanjeeva_joachim_2016,
     title = {Modulating stem cell-substrate interactions and differentiation by controlling substrate topography via microphase separation},
     author = {Arvind, V. and Vega, S. and McCabe, L. H. and Moghe, P. V. and Murthy, S. N. and Kohn, J.},
     journal = {Frontiers in Bioengineering and Biotechnology},
     volume = {4},
     month = mar,
     year = {2016},
     doi = {10.3389/conf.fbioe.2016.01.02444},
   }